John Stamos Hotly Rejects Leaving Wife for Lori Loughlin

During a recent episode of the Good Guys podcast, John Stamos addressed persistent speculation: would he leave his wife, Caitlin McHugh, for his longtime friend and former co-star, Lori Loughlin? He didn’t hesitate to slam the suggestion. “No f—ing way!” he said, making his loyalty crystal clear. 

The question followed a reveal by Stamos that he once hinted in his memoir that Loughlin was “the one that got away” during a brief window when both were single. Still, he insisted their relationship has always been strictly platonic.

From “The One That Got Away” to Bestie Status

Even with the playful mythology built around their “Uncle Jesse and Aunt Becky” romance on Full House, Stamos painted a clear boundary: the past flirtation was fleeting, the present friendship is solid. “Lori was so sweet and I loved working with her … but she was too nice for me,” he admitted.
He also stepped in to defend Loughlin once again — calling her ex-husband Mossimo Giannulli a “terrible narcissist” who dragged her into the scandal surrounding their family. “She deserves better,” he said. 

What This Tells Us About Hollywood Loyalty

This episode highlights something rare in celebrity culture: clarity. Stamos demolished the rumor, reinforced his marriage, and publicly supported a friend in crisis.
He also showed he’s comfortable with the mythos of his past (the “what-if”) without letting it dictate his present. The takeaway? Some Hollywood friendships age better than the romantic fantasies.